Customized Services for Animal Model of Babesia gibsoni Infection
There are two types of Babesia parasiticus (also called Babesia japonica) in dogs, Babesia canis and Babesia gigas. Babesia canis spores usually enter the canine skin through the bloodstream during blood-sucking by ticks (intermediate hosts), and the spores subsequently invade the erythrocytes to form ring-shaped trophozoites, which replicate within the erythrocytes and can form a pair of attached pear-shaped schizonts. The lysosomes can further divide into eight or more reptiles within the same erythrocyte and eventually destroy the erythrocyte releasing Babesia into the bloodstream and thereby infecting more erythrocytes. Babesia is primarily transmitted by tick bites, but can also be transmitted canine-to-canine (vertical transmission, blood transmission, wound transmission).
Babesia gibsoni is a blood parasitic protozoan that seriously affects dogs, foxes, wolves and other animals. Babesia gigas is a tick-borne bloodborne protozoan disease. Babesia gigas can infect red blood cells and cause hemolytic anemia with several clinical signs, including fever, lethargy, anorexia, splenomegaly, and jaundice.
Ace Therapeutics specializes in parasitology and has established a technical platform for the development of animal models of parasitic diseases, aiming to provide development and customization services for various animal models of parasitic diseases for clients worldwide. We provide animal model development services for Babesia gibsoni. This provides a good model for the morphology, life history and especially the molecular biology of Babesia gibsoni and the study of Babesia gigas.
Customization Service Options for Animal Models of Babesia gibsoni Infection
We can construct a Babesia gibsoni model for you in rats, it can be used for scientific research and drug research of Babesia gibsoni. If you want to know more, you are welcome to consult us.
- Rat model of Babesia gibsoni
Model animals: SCID rats (5 to 10 weeks old)
Reproduction method: the spleen was excised after anesthesia and used to replace canine red blood cells and artificially infected with Babesia gibsoni after complete healing of the operated part.
Model characteristics: on the 4th day after infection, a small number of worms could appear in the terminal blood; on the 7th to 8th day, the proliferative worms increased; on the 10th to 12th day, the erythrocyte staining rate could reach about 12%; after that, the worms in the terminal blood began to decrease, which could last for 15 to 18 d, or even for 25 d before the worms disappeared. The proliferation mechanism of Babesia gibsoni in SCID rats is the same as that of Babesia gibsoni, and the clinical symptoms of anemia and hemoglobin reduction are also similar to those of Babesia gibsoni.
Application: this model animal can be used to study the morphology, physiology, biochemistry, proliferation and other biological characteristics of Babesia gibsoni, as well as to study the pathogenesis and screening of therapeutic drugs.
Service Details
Delivery content: experiment report and Babesia gibsoni animal model
Test fee: please get it through online inquiry.
Service Flow
- Communicate your requirements with us via online inquiry or telephone.
- Communicate the requirements (Number, degree of infection, etc.) of Babesia gibsoni animal model customization, sign the contract and pay the deposit.
- Fill out the sample order and send the samples (optional).
- Develop Babesia gibsoni animal model and prepare experiment report.
- Delivery of report and animal model.
Our Advantages
- We offer rat models of Babesia gibsoni that can be used for scientific research and drug research of Babesia gibsoni. If you have special needs, please consult us for customization.
- Our professional technicians have extensive experience in parasite animal model development.
- Advanced technology platform, scientific management system, and standard R&D procedures.
- In addition to Babesia gibsoni animal model customization service, we also provide Babesia gibsoni identification (Blood smear, Giemsa stain, PCR assay, probe method fluorescence quantitative PCR assay, etc.) and in vitro culture services.
- The project cycle time is short and the price is competitive.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
