Parasite resistance is an important issue in public health. With the widespread use of antiparasitic drugs, parasite resistance has emerged and intensified. In order to better understand and address this problem, a large number of parasite resistance studies have been conducted internationally. Major biotechnologies include gene sequencing, proteomics, metabolomics, etc.

Ace Therapeutics has many years of experience in biotechnology research and development and can provide solutions for parasite resistance studies to help our clients better understand and address the issues involved. The solutions we provide have the following advantages: First, we have a highly qualified research team that can provide personalized services according to customer needs. Secondly, we have professional experimental equipment and testing platforms, which can ensure the accuracy and reliability of data. Finally, our services are reasonably priced and can meet the needs of different customers.

Solution Options for Parasite Resistance Research

Ace Therapeutics provides solutions for parasite drug-resistance research, helping clients to conduct relevant research in the following areas:

• Study of multi-drug resistance and cross-resistance of parasites

Ace Therapeutics uses proteomics and metabolomics technologies to analyze the level of parasite resistance to multiple drugs and possible cross-resistance. This helps to gain insight into the mechanisms of parasite resistance to multiple drugs and the causes of cross-resistance, providing a theoretical basis for the development of effective treatment protocols.

• Mechanisms and regulation of parasite drug resistance

Ace Therapeutics combines genomics and transcriptomics technologies to analyze the mechanisms of parasite resistance to drugs and the changes in the expression levels of related genes. An in-depth understanding of the mechanism and regulatory network of parasite resistance to drugs will provide a theoretical basis for the development of new anti-parasitic drugs.

• Molecular marker screening studies for parasite diseases

Ace Therapeutics offers a variety of technologies for molecular marker screening studies of parasitic diseases, mainly through the integrated multi-omics analysis of parasite genomes, transcriptomes, and metabolomes to screen and identify potential therapeutic targets, and high throughput technologies for drug screening, providing the basis for the development of novel anti-parasitic drugs.

• Anti-parasitic drug susceptibility assessment and testing studies

Ace Therapeutics can evaluate the susceptibility of different parasite individuals or strains through several drug susceptibility assessments and testing technologies to provide clients with a basis for appropriate treatment option selection. These techniques include reproduction inhibition assays, cytotoxicity assays, drug metabolic pathway analysis, flow cytometry, etc.

• Mechanism of action and development of novel antiparasitic drugs

For determining the mechanism of action and development of novel antiparasitic drugs, we provide the establishment and use of high-throughput drug screening platforms, including high-performance liquid chromatography-mass spectrometry coupling, cytotoxicity assays, metabolic kinetics, and many other aspects. Through these technical services, we can analyze the toxicity, metabolic processes, and in vitro and in vivo activities of drugs, screen candidate molecules with potential antiparasitic drugs for our clients, and also resolve the molecular mechanisms and modes of action of drugs.

• Anti-parasitic vaccine development and optimization

For the development and optimization of anti-parasitic vaccines, we provide an analysis of the molecular mechanisms of drug resistance based on proteomics, genomics, and metabolomics at multiple levels. We also provide services for the application of gene editing technologies in anti-parasite research, including CRISPR/Cas9-mediated gene knockdown and gene modification. These technologies help clients understand the genetic characteristics and resistance mechanisms of parasites to optimize vaccine design and improve vaccine immunogenicity.

• Genetic diversity of different parasite strains and their impact on resistance to drugs and vaccines

For understanding the genetic diversity of different parasite strains and their impact on resistance to drugs and vaccines, we offer multi-locus mutation screening, genetic diversity analysis, and genomics. We also provide efficient technical services such as flow cytometry, cellular immune separation, and single-cell sequencing to reveal the molecular mechanisms of the host immune response. These technologies help clients gain insight into the genetic background and immune response mechanisms of parasites, thus providing theoretical support for developing novel anti-parasitic drugs and optimizing vaccine design.

In short, Ace Therapeutics provides comprehensive, customized solutions to help clients better understand the molecular mechanisms of parasite drug resistance, conduct relevant research, accelerate the process of new drug development, and provide reliable support in the treatment of parasitic diseases. We are always committed to providing high-quality, personalized services. Welcome to cooperate with us to promote the progress of parasite drug-resistance research. Please consult us to learn more.

• Parasitology discovery and pre-research service
• Parasitology metabolism research service
• Parasitology target and structure function research
• Parasitology effectiveness evaluation service
• Parasitology safety evaluation service
• Parasitology pharmacological research service