Pharmacokinetic Study Services for Anti-parasitic Drugs
Pharmacokinetics of antiparasitic drugs is the discipline that helps to improve the success of antiparasitic drug development by designing and performing various in vivo and in vitro pharmacokinetic studies based on drug development needs. It mainly refers to the use of mathematical processing to quantitatively describe the dynamics of antiparasitic drugs or other exogenous substances in the human body, and thus to study the toxicological and pharmacological implications of the absorption, distribution, metabolism, and excretion (ADME) of drugs in humans. The basis for determining the dose and interval of drug administration is the ability of the drug to reach a safe and effective concentration at its site of action. The concentration of the drug at the site of action is dynamically influenced by the in vivo processes of the drug. Currently, pharmacokinetics has penetrated into many disciplines such as pharmacotherapeutics, biopharmacology, and toxicology, and is used throughout the development of drugs, becoming an important hallmark of today's in-depth drug research. In the development of innovative antiparasitic drugs, pharmacokinetic studies are as important as pharmacodynamic and toxicological studies and have become an important part of preclinical and clinical studies of antiparasitic drugs.
Ace Therapeutics' pharmacokinetic laboratory is GLP certified by NMPA, and experimental studies follow the guidelines of ICH, NMPA, and FDA. We can design and conduct in vivo and in vitro pharmacokinetic tests according to clients' needs, and provide a complete set of pharmacokinetic evaluation and optimization services for our clients. We are recognized by our international clients for our high-quality data to meet the needs of different stages of new drug development.
Service Items of Pharmacokinetic Study of Antiparasitic Drugs
| In vitro ADME research services items |
- Uptake —Caco-2 permeability transmembrane transport assay (Caco-2 drug transport assay, P-gp drug transport assay, BCRP drug transport assay, OATs/OCTs/OATPs, etc.)
- Distribution — Protein binding rate (plasma/tissue/microsomes) whole blood/plasma partition test
- Metabolism — metabolic stability (liver microsomal stability test, S9 stability test, hepatocyte metabolic stability test, plasma, and whole blood stability test)
- Matrix stability — Plasma, tissue, and buffer in vitro metabolite analysis and identification (metabolite speculation, corroboration. metabolic pathway speculation, corroboration)
- Drug-drug interactions — Cytochrome P450 (CYP) inhibition (IC50 and TDI)
- P450-inducible enzyme phenotypic analysis — Phase I and II enzymes (recombinant enzymes and chemo suppression)
- Formulation property analysis — Formulation optimization, lipophilicity, solubility testing
- In vitro toxicity —Ames, Mini-Ames, chromosomal aberrations, TK gene mutations, etc.
- Rapid screening or support IND filing
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| In vivo PK research service items |
- Plasma kinetic studies
- Tissue distribution studies
- Excretion studies
- Material balance
- Blood-brain barrier
- ADC pharmacokinetic evaluation, etc.
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Quotation and Ordering
In order to provide an efficient and accurate quote, please complete the online inquiry form and send it to us, we will reply to you the first time. Feel free to consult us for more details about our services.
Our Advantages
- As a global pharmacokinetic research service provider, we are committed to being the pharmacokinetic research partner of choice for all our clients by providing high-quality data, accurate development strategies, and excellent service to meet their individual project needs.
- Our studies include in vitro absorption, distribution, metabolism, and excretion (ADME) studies of antiparasitic drugs, as well as in vivo pharmacokinetic studies. In addition, we can provide services for drug-drug interactions, metabolite identification (in vivo/ex vivo biotransformation), quantitative radioautography studies, human radioactive material homeostasis, and metabolite safety evaluation studies.
- Our anti-parasitic drug research services have a diverse client base that includes major pharmaceutical companies, biopharmaceutical companies, virtual pharmaceutical companies, non-profit organizations, and academic institutions worldwide.
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.
